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J Scott Daniels

Showing results (71-80 of 122) with videos related to

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Journal of Medicinal Chemistry|November 26, 2014
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)Lindsey C Morris, Kellie D Nance, Patrick R Gentry, et al.
ACS Chemical Biology|August 20, 2014
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsHyekyung P Cho, Pedro M Garcia-Barrantes, John T Brogan, et al.
Journal of Medicinal Chemistry|October 30, 2013
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|December 15, 2012
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe moleculeBruce J Melancon, Michael S Poslusney, Patrick R Gentry, et al.
ACS Chemical Neuroscience|July 22, 2016
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 HeteromersColleen M Niswender, Carrie K Jones, Xin Lin, et al.
Bioorganic & Medicinal Chemistry Letters|June 19, 2004
Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R)Thomas H Marsilje, Jonathan B Roses, Emily F Calderwood, et al.
ACS Chemical Neuroscience|June 5, 2013
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in miceKristian Kaufmann, Ian Romaine, Emily Days, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 4, 2013
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanismThomas M Bridges, Jerri M Rook, Meredith J Noetzel, et al.
Bioorganic & Medicinal Chemistry Letters|September 21, 2011
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071Evan P Lebois, Gregory J Digby, Douglas J Sheffler, et al.
Bioorganic & Medicinal Chemistry Letters|June 28, 2014
Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyBrittney S Bates, Alice L Rodriguez, Andrew S Felts, et al.
Pageof 13

Showing results (71-80 of 122) with videos related to

Sort By:
Pageof 13
Journal of Medicinal Chemistry|November 26, 2014
Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[3,4-b]indole-4-carboxamide (VU0453379): a novel, CNS penetrant glucagon-like peptide 1 receptor (GLP-1R) positive allosteric modulator (PAM)Lindsey C Morris, Kellie D Nance, Patrick R Gentry, et al.
ACS Chemical Biology|August 20, 2014
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenicsHyekyung P Cho, Pedro M Garcia-Barrantes, John T Brogan, et al.
Journal of Medicinal Chemistry|October 30, 2013
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|December 15, 2012
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe moleculeBruce J Melancon, Michael S Poslusney, Patrick R Gentry, et al.
ACS Chemical Neuroscience|July 22, 2016
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 HeteromersColleen M Niswender, Carrie K Jones, Xin Lin, et al.
Bioorganic & Medicinal Chemistry Letters|June 19, 2004
Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R)Thomas H Marsilje, Jonathan B Roses, Emily F Calderwood, et al.
ACS Chemical Neuroscience|June 5, 2013
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in miceKristian Kaufmann, Ian Romaine, Emily Days, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 4, 2013
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanismThomas M Bridges, Jerri M Rook, Meredith J Noetzel, et al.
Bioorganic & Medicinal Chemistry Letters|September 21, 2011
Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071Evan P Lebois, Gregory J Digby, Douglas J Sheffler, et al.
Bioorganic & Medicinal Chemistry Letters|June 28, 2014
Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyBrittney S Bates, Alice L Rodriguez, Andrew S Felts, et al.
Pageof 13