Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Filters

J Scott Daniels

Showing results (81-90 of 122) with videos related to

Pageof 13
Sort By:
Chemmedchem|April 3, 2014
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probePatrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|May 2, 2016
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacyRocco D Gogliotti, Darren W Engers, Pedro M Garcia-Barrantes, et al.
Bioorganic & Medicinal Chemistry Letters|June 29, 2012
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptorJames M Salovich, Paige N Vinson, Douglas J Sheffler, et al.
Bioorganic & Medicinal Chemistry Letters|September 30, 2017
Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5Andrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.
Science Translational Medicine|August 18, 2017
mGlu<sub>7</sub> potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndromeRocco G Gogliotti, Rebecca K Senter, Nicole M Fisher, et al.
Bioorganic & Medicinal Chemistry Letters|October 1, 2013
Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyAndrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.
Bioorganic & Medicinal Chemistry Letters|December 27, 2011
Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012Bruce J Melancon, Alexander P Lamers, Thomas M Bridges, et al.
Molecular Pharmacology|October 25, 2011
Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system functionMeredith J Noetzel, Jerri M Rook, Paige N Vinson, et al.
Journal of Medicinal Chemistry|November 3, 2015
Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2Andrew S Felts, Alice L Rodriguez, Katrina A Smith, et al.
The Journal of Pharmacology and Experimental Therapeutics|March 19, 2010
A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammationRobert J Mourey, Barry L Burnette, Sarah J Brustkern, et al.
Pageof 13

Showing results (81-90 of 122) with videos related to

Sort By:
Pageof 13
Chemmedchem|April 3, 2014
Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probePatrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|May 2, 2016
Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacyRocco D Gogliotti, Darren W Engers, Pedro M Garcia-Barrantes, et al.
Bioorganic & Medicinal Chemistry Letters|June 29, 2012
Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptorJames M Salovich, Paige N Vinson, Douglas J Sheffler, et al.
Bioorganic & Medicinal Chemistry Letters|September 30, 2017
Discovery of imidazo[1,2-a]-, [1,2,4]triazolo[4,3-a]-, and [1,2,4]triazolo[1,5-a]pyridine-8-carboxamide negative allosteric modulators of metabotropic glutamate receptor subtype 5Andrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.
Science Translational Medicine|August 18, 2017
mGlu<sub>7</sub> potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndromeRocco G Gogliotti, Rebecca K Senter, Nicole M Fisher, et al.
Bioorganic & Medicinal Chemistry Letters|October 1, 2013
Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxietyAndrew S Felts, Alice L Rodriguez, Ryan D Morrison, et al.
Bioorganic & Medicinal Chemistry Letters|December 27, 2011
Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012Bruce J Melancon, Alexander P Lamers, Thomas M Bridges, et al.
Molecular Pharmacology|October 25, 2011
Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system functionMeredith J Noetzel, Jerri M Rook, Paige N Vinson, et al.
Journal of Medicinal Chemistry|November 3, 2015
Design of 4-Oxo-1-aryl-1,4-dihydroquinoline-3-carboxamides as Selective Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 2Andrew S Felts, Alice L Rodriguez, Katrina A Smith, et al.
The Journal of Pharmacology and Experimental Therapeutics|March 19, 2010
A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammationRobert J Mourey, Barry L Burnette, Sarah J Brustkern, et al.
Pageof 13