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Journal of Medicinal Chemistry|June 12, 2018
Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based DesignFeng Wang, Kyu Ok Jeon, James M Salovich, et al.Journal of Medicinal Chemistry|January 12, 2026
Discovery of Fragment-Based Inhibitors of SARS-CoV-2 PLProQiangqiang Wei, Ashley J Taylor, Mahesh Angadrao Barmade, et al.Journal of Medicinal Chemistry|October 27, 2022
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C InhibitorJoachim Bröker, Alex G Waterson, Chris Smethurst, et al.Journal of Medicinal Chemistry|September 12, 2018
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RASTimothy R Hodges, Jason R Abbott, Andrew J Little, et al.Journal of Medicinal Chemistry|July 25, 2025
Discovery of BI-2493, a Pan-KRAS Inhibitor Showing In Vivo EfficacyJoachim Bröker, Alex G Waterson, Timothy R Hodges, et al.Journal of Medicinal Chemistry|November 15, 2019
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein InteractionJonathan D Macdonald, Selena Chacón Simon, Changho Han, et al.Cell Reports|March 14, 2019
Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar AffinityErin R Aho, Jing Wang, Rocco D Gogliotti, et al.Journal of Medicinal Chemistry|March 30, 2026
Identification of KLHL12 Ligands Using Fragment-Based MethodsAlex G Waterson, Anish Vadukoot, Somnath Jana, et al.Proceedings of the National Academy of Sciences of the United States of America|July 24, 2019
Drugging an undruggable pocket on KRASDirk Kessler, Michael Gmachl, Andreas Mantoulidis, et al.Pageof 4