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Journal of Medicinal Chemistry|December 12, 2023
Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 InhibitorsKevin B Teuscher, Jonathan J Mills, Jianhua Tian, et al.Journal of Medicinal Chemistry|June 12, 2018
Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based DesignFeng Wang, Kyu Ok Jeon, James M Salovich, et al.Proceedings of the National Academy of Sciences of the United States of America|December 27, 2022
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal modelsKevin B Teuscher, Somenath Chowdhury, Kenneth M Meyers, et al.Journal of Medicinal Chemistry|September 12, 2018
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RASTimothy R Hodges, Jason R Abbott, Andrew J Little, et al.Journal of Medicinal Chemistry|November 15, 2019
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein InteractionJonathan D Macdonald, Selena Chacón Simon, Changho Han, et al.Journal of Medicinal Chemistry|December 21, 2019
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic CoreJianhua Tian, Kevin B Teuscher, Erin R Aho, et al.Journal of Medicinal Chemistry|March 30, 2026
Identification of KLHL12 Ligands Using Fragment-Based MethodsAlex G Waterson, Anish Vadukoot, Somnath Jana, et al.Proceedings of the National Academy of Sciences of the United States of America|July 24, 2019
Drugging an undruggable pocket on KRASDirk Kessler, Michael Gmachl, Andreas Mantoulidis, et al.Pageof 4