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Journal of the American Chemical Society|July 12, 2017
How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S1' Pocket of ThermolysinStefan G Krimmer, Jonathan Cramer, Johannes Schiebel, et al.Structure (London, England : 1993)|May 15, 2012
Staphylococcus aureus FabI: inhibition, substrate recognition, and potential implications for in vivo essentialityJohannes Schiebel, Andrew Chang, Hao Lu, et al.Structure (London, England : 1993)|December 9, 2014
FadA5 a thiolase from Mycobacterium tuberculosis: a steroid-binding pocket reveals the potential for drug development against tuberculosisChristin M Schaefer, Rui Lu, Natasha M Nesbitt, et al.Angewandte Chemie (International Ed. in English)|April 4, 2017
Charges Shift Protonation: Neutron Diffraction Reveals that Aniline and 2-Aminopyridine Become Protonated Upon Binding to TrypsinJohannes Schiebel, Roberto Gaspari, Anna Sandner, et al.The Journal of Biological Chemistry|October 11, 2013
Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosisJohannes Schiebel, Kanishk Kapilashrami, Agnes Fekete, et al.Nature Communications|September 5, 2018
Intriguing role of water in protein-ligand binding studied by neutron crystallography on trypsin complexesJohannes Schiebel, Roberto Gaspari, Tobias Wulsdorf, et al.Journal of Medicinal Chemistry|January 20, 2021
How a Fragment Draws Attention to Selectivity Discriminating Features between the Related Proteases Trypsin and ThrombinAnna Sandner, Khang Ngo, Johannes Schiebel, et al.Acta Crystallographica. Section F, Structural Biology Communications|May 4, 2016
Structures of endothiapepsin-fragment complexes from crystallographic fragment screening using a novel, diverse and affordable 96-compound fragment libraryFranziska U Huschmann, Janina Linnik, Karine Sparta, et al.Biochemistry|May 24, 2013
Rational optimization of drug-target residence time: insights from inhibitor binding to the Staphylococcus aureus FabI enzyme-product complexAndrew Chang, Johannes Schiebel, Weixuan Yu, et al.Chemical Science|August 23, 2016
Correlating Drug-Target Kinetics and In vivo Pharmacodynamics: Long Residence Time Inhibitors of the FabI Enoyl-ACP ReductaseFereidoon Daryaee, Andrew Chang, Johannes Schiebel, et al.Pageof 2