Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Filters

Joseph P Vacca

Showing results (31-40 of 84) with videos related to

Pageof 9
Sort By:
Bioorganic & Medicinal Chemistry Letters|August 26, 2009
Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibilityMichael R Wood, Kathy M Schirripa, June J Kim, et al.
Journal of Medicinal Chemistry|October 13, 2007
Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)Daniel V Paone, Anthony W Shaw, Diem N Nguyen, et al.
Chemmedchem|October 16, 2013
Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activityCraig A Coburn, Peter T Meinke, Wei Chang, et al.
Journal of the American Chemical Society|March 15, 2008
Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A proteaseNigel J Liverton, M Katharine Holloway, John A McCauley, et al.
Bioorganic & Medicinal Chemistry Letters|May 5, 2009
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1Shawn J Stachel, Craig A Coburn, Diane Rush, et al.
Annals of the New York Academy of Sciences|March 26, 2011
Raltegravir: the first HIV-1 integrase strand transfer inhibitor in the HIV armamentariumBach-Yen T Nguyen, Robin D Isaacs, Hedy Teppler, et al.
Bioorganic & Medicinal Chemistry Letters|February 4, 2010
Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitorsHong Zhu, Mary B Young, Philippe G Nantermet, et al.
Bioorganic & Medicinal Chemistry Letters|July 21, 2004
Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailabilityMatthew M Morrissette, Kenneth J Stauffer, Peter D Williams, et al.
Journal of Medicinal Chemistry|December 4, 2003
Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithromboticsJames C Barrow, Philippe G Nantermet, Shaun R Stauffer, et al.
Bioorganic & Medicinal Chemistry Letters|April 9, 2008
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutationsThomas J Tucker, Sandeep Saggar, John T Sisko, et al.
Pageof 9

Showing results (31-40 of 84) with videos related to

Sort By:
Pageof 9
Bioorganic & Medicinal Chemistry Letters|August 26, 2009
Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibilityMichael R Wood, Kathy M Schirripa, June J Kim, et al.
Journal of Medicinal Chemistry|October 13, 2007
Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)Daniel V Paone, Anthony W Shaw, Diem N Nguyen, et al.
Chemmedchem|October 16, 2013
Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activityCraig A Coburn, Peter T Meinke, Wei Chang, et al.
Journal of the American Chemical Society|March 15, 2008
Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A proteaseNigel J Liverton, M Katharine Holloway, John A McCauley, et al.
Bioorganic & Medicinal Chemistry Letters|May 5, 2009
Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1Shawn J Stachel, Craig A Coburn, Diane Rush, et al.
Annals of the New York Academy of Sciences|March 26, 2011
Raltegravir: the first HIV-1 integrase strand transfer inhibitor in the HIV armamentariumBach-Yen T Nguyen, Robin D Isaacs, Hedy Teppler, et al.
Bioorganic & Medicinal Chemistry Letters|February 4, 2010
Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitorsHong Zhu, Mary B Young, Philippe G Nantermet, et al.
Bioorganic & Medicinal Chemistry Letters|July 21, 2004
Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailabilityMatthew M Morrissette, Kenneth J Stauffer, Peter D Williams, et al.
Journal of Medicinal Chemistry|December 4, 2003
Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithromboticsJames C Barrow, Philippe G Nantermet, Shaun R Stauffer, et al.
Bioorganic & Medicinal Chemistry Letters|April 9, 2008
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutationsThomas J Tucker, Sandeep Saggar, John T Sisko, et al.
Pageof 9