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Cancer Discovery|August 21, 2020
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK InhibitionMarco H Hofmann, Michael Gmachl, Juergen Ramharter, et al.Nature Chemical Biology|June 11, 2019
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC designWilliam Farnaby, Manfred Koegl, Michael J Roy, et al.Nature Chemical Biology|July 4, 2019
Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC designWilliam Farnaby, Manfred Koegl, Michael J Roy, et al.Journal of Medicinal Chemistry|August 1, 2019
Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor <b>BI-4924</b> Disrupts Serine BiosynthesisHarald Weinstabl, Matthias Treu, Joerg Rinnenthal, et al.Nature Cancer|August 5, 2024
Co-targeting SOS1 enhances the antitumor effects of KRAS<sup>G12C</sup> inhibitors by addressing intrinsic and acquired resistanceVenu Thatikonda, Hengyu Lyu, Sabine Jurado, et al.Nature Cancer|July 26, 2022
Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signalingBirgit Wilding, Dirk Scharn, Dietrich Böse, et al.Proceedings of the National Academy of Sciences of the United States of America|July 24, 2019
Drugging an undruggable pocket on KRASDirk Kessler, Michael Gmachl, Andreas Mantoulidis, et al.Cell Reports|September 21, 2017
Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6Nina Kerres, Steffen Steurer, Stefanie Schlager, et al.Nature Chemical Biology|July 10, 2019
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3Jark Böttcher, David Dilworth, Ulrich Reiser, et al.Pageof 24