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Chemical Biology & Drug Design|October 22, 2009
Resveratrol is not a direct activator of SIRT1 enzyme activityDirk Beher, John Wu, Suzanne Cumine, et al.Assay and Drug Development Technologies|May 21, 2010
Strategy for the identification of GPR23/LPA4 receptor agonists and inverse agonistsSoo Hang Wong, Rommel Mallari, Melissa Graham, et al.Journal of Lipid Research|January 31, 2012
An apoA-I mimetic peptibody generates HDL-like particles and increases alpha-1 HDL subfraction in miceShu-Chen Lu, Larissa Atangan, Ki Won Kim, et al.Nature Communications|October 6, 2020
Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonismElizabeth A Killion, Michelle Chen, James R Falsey, et al.The Journal of Pharmacology and Experimental Therapeutics|September 2, 2009
Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemiaWei Gu, Hai Yan, Katherine A Winters, et al.Cell Reports. Medicine|June 7, 2021
GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeysShu-Chen Lu, Michelle Chen, Larissa Atangan, et al.Nature Metabolism|February 5, 2024
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settingsMurielle M Véniant, Shu-Chen Lu, Larissa Atangan, et al.Journal of Medicinal Chemistry|April 6, 2026
Discovery of AMG 133, a Glucose-Dependent Insulinotropic Polypeptide Receptor Antagonist and Glucagon-Like Peptide 1 Receptor Agonist Antibody-Drug Conjugate for the Treatment of ObesityBin Wu, James R Falsey, Chawita Netirojjanakul, et al.Science Translational Medicine|December 21, 2018
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical modelsElizabeth A Killion, Jinghong Wang, Junming Yie, et al.Pageof 1