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M Bridges

Showing results (331-340 of 403) with videos related to

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Biological Psychiatry|May 19, 2020
MEF2C Hypofunction in Neuronal and Neuroimmune Populations Produces MEF2C Haploinsufficiency Syndrome-like Behaviors in MiceAdam J Harrington, Catherine M Bridges, Stefano Berto, et al.
Human Molecular Genetics|March 4, 2016
mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndromeRocco G Gogliotti, Rebecca K Senter, Jerri M Rook, et al.
Neuropharmacology|July 22, 2017
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M<sub>4</sub> PAM VU0467154Robert W Gould, Michael D Grannan, Barak W Gunter, et al.
Investigative Ophthalmology & Visual Science|November 10, 2021
Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma ModelJessica V Kaczmarek, Carley M Bogan, Janene M Pierce, et al.
Journal of Medicinal Chemistry|October 30, 2013
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|December 15, 2012
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe moleculeBruce J Melancon, Michael S Poslusney, Patrick R Gentry, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 4, 2013
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanismThomas M Bridges, Jerri M Rook, Meredith J Noetzel, et al.
Molecular Pharmacology|May 2, 2009
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learningDouglas J Sheffler, Richard Williams, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|September 21, 2019
Discovery of a novel 3,4-dimethylcinnoline carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotype via scaffold hoppingKayla J Temple, Julie L Engers, Madeline F Long, et al.
ACS Medicinal Chemistry Letters|May 14, 2025
Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor <i>in Vivo</i> Tool CompoundMotoyuki Tanaka, Takahiro Mori, Gakuji Hashimoto, et al.
Pageof 41

Showing results (331-340 of 403) with videos related to

Sort By:
Pageof 41
Biological Psychiatry|May 19, 2020
MEF2C Hypofunction in Neuronal and Neuroimmune Populations Produces MEF2C Haploinsufficiency Syndrome-like Behaviors in MiceAdam J Harrington, Catherine M Bridges, Stefano Berto, et al.
Human Molecular Genetics|March 4, 2016
mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndromeRocco G Gogliotti, Rebecca K Senter, Jerri M Rook, et al.
Neuropharmacology|July 22, 2017
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M<sub>4</sub> PAM VU0467154Robert W Gould, Michael D Grannan, Barak W Gunter, et al.
Investigative Ophthalmology & Visual Science|November 10, 2021
Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma ModelJessica V Kaczmarek, Carley M Bogan, Janene M Pierce, et al.
Journal of Medicinal Chemistry|October 30, 2013
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|December 15, 2012
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe moleculeBruce J Melancon, Michael S Poslusney, Patrick R Gentry, et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals|July 4, 2013
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanismThomas M Bridges, Jerri M Rook, Meredith J Noetzel, et al.
Molecular Pharmacology|May 2, 2009
A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learningDouglas J Sheffler, Richard Williams, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters|September 21, 2019
Discovery of a novel 3,4-dimethylcinnoline carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotype via scaffold hoppingKayla J Temple, Julie L Engers, Madeline F Long, et al.
ACS Medicinal Chemistry Letters|May 14, 2025
Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor <i>in Vivo</i> Tool CompoundMotoyuki Tanaka, Takahiro Mori, Gakuji Hashimoto, et al.
Pageof 41