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Discovery Immunology|March 1, 2023
Protection from T cell-dependent colitis by the helminth-derived immunomodulatory mimic of transforming growth factor-β, Hp-TGMDanielle J Smyth, Madeleine P J White, Chris J C Johnston, et al.Journal of Biotechnology|August 14, 2021
Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS modelDanielle J Smyth, Bijie Ren, Madeleine P J White, et al.International Journal for Parasitology|March 7, 2018
TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrusDanielle J Smyth, Yvonne Harcus, Madeleine P J White, et al.Mucosal Immunology|March 15, 2022
The IL-25-dependent tuft cell circuit driven by intestinal helminths requires macrophage migration inhibitory factor (MIF)Fumi Varyani, Stephan Löser, Kara J Filbey, et al.Communications Biology|June 4, 2021
The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and functionBergithe E Oftedal, Stefano Maio, Adam E Handel, et al.Biorxiv : the Preprint Server for Biology|January 8, 2024
TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblastsStephen E White, Tristin A Schwartze, Ananya Mukundan, et al.Nature Communications|February 21, 2025
TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblastsStephen E White, Tristin A Schwartze, Ananya Mukundan, et al.Biorxiv : the Preprint Server for Biology|November 28, 2023
The helminth TGF-β mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-β receptors to preferentially target myeloid cellsShashi P Singh, Danielle J Smyth, Kyle Cunningham, et al.Proceedings of the National Academy of Sciences of the United States of America|August 17, 2023
CD44 acts as a coreceptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimicMaarten van Dinther, Kyle T Cunningham, Shashi Prakash Singh, et al.EMBO Reports|November 28, 2024
The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor bindingShashi P Singh, Danielle J Smyth, Kyle T Cunningham, et al.Pageof 3