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Journal of Medicinal Chemistry|November 17, 2018
Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer TherapyZheng-Yu Jiang, Meng-Chen Lu, Qi-Dong YouJournal of Medicinal Chemistry|October 4, 2016
Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction Inhibitors: Achievements, Challenges, and Future DirectionsZheng-Yu Jiang, Meng-Chen Lu, Qi-Dong YouMedicinal Research Reviews|May 19, 2016
The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An UpdateMeng-Chen Lu, Jian-Ai Ji, Zheng-Yu Jiang, et al.European Journal of Medicinal Chemistry|September 1, 2020
Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditionsMeng-Chen Lu, Hong-Li Shao, Tian Liu, et al.Journal of Medicinal Chemistry|July 9, 2019
Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced HepatotoxicityMeng-Chen Lu, Xian Zhang, Feng Wu, et al.Molecular Biosystems|March 4, 2016
A systematic molecular dynamics approach to the study of peptide Keap1-Nrf2 protein-protein interaction inhibitors and its application to p62 peptidesMeng-Chen Lu, Zhen-Wei Yuan, Yong-Lin Jiang, et al.European Journal of Medicinal Chemistry|November 10, 2017
Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potencyMeng-Chen Lu, Qiong Jiao, Tian Liu, et al.Redox Biology|July 8, 2019
CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activationMeng-Chen Lu, Jing Zhao, Yu-Ting Liu, et al.Journal of Medicinal Chemistry|March 11, 2020
Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein KnockdownYu-Hui Jin, Meng-Chen Lu, Yan Wang, et al.ACS Medicinal Chemistry Letters|September 24, 2016
Polar Recognition Group Study of Keap1-Nrf2 Protein-Protein Interaction InhibitorsMeng-Chen Lu, Shi-Jie Tan, Jian-Ai Ji, et al.Pageof 2