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Journal of Medicinal Chemistry|July 4, 2009
Identification of inhibitors of checkpoint kinase 1 through template screeningThomas P Matthews, Suki Klair, Samantha Burns, et al.Chemical Science|November 27, 2024
Sequence-defined phosphoestamers for selective inhibition of the KRASG12D/RAF1 interactionBini Claringbold, Steven Vance, Alexandra R Paul, et al.Oncogene|November 7, 2003
Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomersMichela Perani, Catherine J E Ingram, Colin S Cooper, et al.Journal of Medicinal Chemistry|December 29, 2010
Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2John J Caldwell, Emma J Welsh, Cornelis Matijssen, et al.The Biochemical Journal|March 17, 2017
Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathwayIan Collins, Hannah Wang, John J Caldwell, et al.Plos One|June 19, 2013
Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2M Cris Silva-Santisteban, Isaac M Westwood, Kathy Boxall, et al.Molecular Oncology|December 22, 2015
Novel pharmacodynamic biomarkers for MYCN protein and PI3K/AKT/mTOR pathway signaling in children with neuroblastomaJennifer R Smith, Lucas Moreno, Simon P Heaton, et al.Current Opinion in Pharmacology|August 30, 2008
Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promisesTimothy A Yap, Michelle D Garrett, Mike I Walton, et al.Bioorganic & Medicinal Chemistry|October 27, 2005
Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase BIan Collins, John Caldwell, Tatiana Fonseca, et al.Journal of Medicinal Chemistry|October 23, 2012
Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitorsMichael Lainchbury, Thomas P Matthews, Tatiana McHardy, et al.Pageof 15