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Journal of Medicinal Chemistry|August 20, 2010
Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiencyChristopher W Murray, Maria G Carr, Owen Callaghan, et al.Journal of Medicinal Chemistry|June 20, 2020
Structure-Based Drug Discovery of N-((R)-3-(7-Methyl-1H-indazol-5-yl)-1-oxo-1-(((S)-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2'-oxo-1',2'-dihydrospiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of MigraineSarah J Bucknell, Mark A Ator, Alastair J H Brown, et al.ANZ Journal of Surgery|August 26, 2021
Correlation of magnetic resonance and arthroscopy in the diagnosis of shoulder injuryPatrick Groarke, Simond Jagernauth, Susan E Peters, et al.Journal of Medicinal Chemistry|November 8, 2007
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiencyPhilip D Edwards, Jeffrey S Albert, Mark Sylvester, et al.Journal of Medicinal Chemistry|December 21, 2019
Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational AnalysisMathieu Rappas, Ammar A E Ali, Kirstie A Bennett, et al.Journal for Immunotherapy of Cancer|July 31, 2020
Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunityAlexandra Borodovsky, Christine M Barbon, Yanjun Wang, et al.ACS Chemical Neuroscience|March 4, 2022
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand ComplexesAndrew D Cansfield, Mark A Ator, Joydeep Banerjee, et al.Bioorganic & Medicinal Chemistry Letters|August 27, 2019
Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug designAlistair O'Brien, Stephen P Andrews, Asma H Baig, et al.Journal of Medicinal Chemistry|July 29, 2010
Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug designAndrew J Woodhead, Hayley Angove, Maria G Carr, et al.International Journal of Circumpolar Health|March 11, 2022
Abstracts from The Cold Weather Operations Conference 2021Arne Johan Norheim, Bård Rannestad, Richard Howes, et al.Pageof 6