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Communications Biology|May 24, 2026
A heterobifunctional IRAK4-targeting degrader impairs myddosome signaling in acute kidney injury and ameliorates kidney fibrosisMarta Lopez-Marfil, Xichi Wang, Diana Ofelia Lopez-Cantu, et al.
Toxicological Sciences : an Official Journal of the Society of Toxicology|December 12, 2025
Developmental Toxicology Profile of the IRAK4 Degrader KT-474Bradley E Enerson, Gregg Cappon, Yatao Shi, et al.
Cell Metabolism|January 24, 2017
Serine Is an Essential Metabolite for Effector T Cell ExpansionEric H Ma, Glenn Bantug, Takla Griss, et al.
Journal of Medicinal Chemistry|June 26, 2024
Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell LymphomaMatthew M Weiss, Xiaozhang Zheng, Nan Ji, et al.
Frontiers in Immunology|January 30, 2026
Targeted degradation of MK2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MK3 and MK5Bin Yang, Guoqiang Fang, Isaac Marx, et al.
Nature Communications|January 15, 2021
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapyMylène Tajan, Marc Hennequart, Eric C Cheung, et al.
Nature Chemical Biology|June 19, 2019
A small-molecule inhibitor of C5 complement proteinKeith Jendza, Mitsunori Kato, Michael Salcius, et al.
Molecular Cancer Therapeutics|December 9, 2024
KT-253, a Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy than MDM2 Small-Molecule InhibitorsYogesh K Chutake, Michele F Mayo, Nancy Dumont, et al.
Journal of Medicinal Chemistry|August 16, 2024
Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune DiseasesXiaozhang Zheng, Nan Ji, Veronica Campbell, et al.
Journal of Medicinal Chemistry|November 17, 2015
Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular DegenerationErik L Meredith, Nello Mainolfi, Stephen Poor, et al.
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