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Current Opinion in Biotechnology|July 5, 2005
Semi-rational approaches to engineering enzyme activity: combining the benefits of directed evolution and rational designRoberto A Chica, Nicolas Doucet, Joelle N Pelletier
Scientific Reports|June 11, 2017
Conserved amino acid networks modulate discrete functional properties in an enzyme superfamilyChitra Narayanan, Donald Gagné, Kimberly A Reynolds, et al.
The Journal of Biological Chemistry|August 25, 2004
Site-saturation mutagenesis of Tyr-105 reveals its importance in substrate stabilization and discrimination in TEM-1 beta-lactamaseNicolas Doucet, Pierre-Yves De Wals, Joelle N Pelletier
Protein Engineering, Design & Selection : PEDS|November 23, 2022
Integrating dynamics into enzyme engineeringClaudèle Lemay-St-Denis, Nicolas Doucet, Joelle N Pelletier
Protein Science : a Publication of the Protein Society|December 11, 2014
Combinatorial active-site variants confer sustained clavulanate resistance in BlaC β-lactamase from Mycobacterium tuberculosisPhilippe Egesborg, Hélène Carlettini, Jordan P Volpato, et al.
Protein Science : a Publication of the Protein Society|January 30, 2009
High tolerance to simultaneous active-site mutations in TEM-1 beta-lactamase: Distinct mutational paths provide more generalized beta-lactam recognitionPierre-Yves De Wals, Nicolas Doucet, Joelle N Pelletier
Biochemistry|January 22, 2011
Alteration of hydrogen bonding in the vicinity of histidine 48 disrupts millisecond motions in RNase ANicolas Doucet, Gennady Khirich, Evgenii L Kovrigin, et al.
International Journal of Radiation Biology|May 2, 2013
Effect of combination of essential oils and bacteriocins on the efficacy of gamma radiation against Salmonella Typhimurium and Listeria monocytogenesAude Ndoti-Nembe, Khanh Dang Vu, Nicolas Doucet, et al.
Chemcatchem|April 26, 2021
Enzyme dynamics: Looking beyond a single structurePratul K Agarwal, David N Bernard, Khushboo Bafna, et al.
Proteins|July 6, 2010
The crystal structure of ribonuclease A in complex with thymidine-3'-monophosphate provides further insight into ligand bindingNicolas Doucet, Thusitha B Jayasundera, Miljan Simonović, et al.
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