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Therapeutic Innovation & Regulatory Science|July 7, 2026
Different Clinical Questions Need Different EstimandsOliver Keene, Helle Lynggaard, Christine Fletcher, et al.BMC Medicine|July 27, 2023
Why estimands are needed to define treatment effects in clinical trialsOliver N Keene, Helle Lynggaard, Stefan Englert, et al.British Journal of Clinical Pharmacology|November 26, 2024
Applying the estimand framework to clinical pharmacology trials with a case study in bioequivalenceHelle Lynggaard, Sue McKendrick, Mark Baird, et al.Contemporary Clinical Trials|May 25, 2005
Design and analysis of trials with rare outcomes: examples from trials in herpes transmission and influenza prophylaxisOliver KeenePharmaceutical Statistics|July 21, 2023
Adherence, per-protocol effects, and the estimands frameworkOliver KeeneCurrent Medical Research and Opinion|September 3, 2014
The SimpleMix study with biphasic insulin aspart 30: a randomized controlled trial investigating patient-driven titration versus investigator-driven titrationYan Gao, Cecilia Luquez, Helle Lynggaard, et al.Trials|August 19, 2022
Principles and recommendations for incorporating estimands into clinical study protocol templatesHelle Lynggaard, James Bell, Christian Lösch, et al.Clinical Nurse Specialist CNS|December 1, 2018
Examining the Perceived Effects of an Adult Day Program for Individuals With Dementia and Their Caregivers: A Qualitative InvestigationKaren Helena Thompson, Paula Christine FletcherThe Journal of Sexual Medicine|January 8, 2018
Efficacy and Safety of MED2005, a Topical Glyceryl Trinitrate Formulation, in the Treatment of Erectile Dysfunction: A Randomized Crossover StudyDavid J Ralph, Ian Eardley, Jorg Taubel, et al.Pageof 51