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ACS Medicinal Chemistry Letters
|
September 28, 2018
VU6007477, a Novel M<sub>1</sub> PAM Based on a Pyrrolo[2,3-<i>b</i>]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events
Julie L Engers, Elizabeth S Childress, Madeline F Long, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|
March 28, 2018
M<sub>1</sub>-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition
Sean P Moran, Jonathan W Dickerson, Hyekyung P Cho, et al.
Hepatology (Baltimore, Md.)
|
September 26, 2020
ABIDE: An Accurate Predictive Model of Liver Decompensation in Patients With Nonalcoholic Fatty Liver-Related Cirrhosis
Luis Calzadilla-Bertot, Eduardo Vilar-Gomez, Vincent Wai-Sun Wong, et al.
Journal of Medicinal Chemistry
|
January 5, 2019
Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu<sub>7</sub> Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1 H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962)
Carson W Reed, Samantha E Yohn, Jordan P Washecheck, et al.
ACS Chemical Biology
|
August 20, 2014
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics
Hyekyung P Cho, Pedro M Garcia-Barrantes, John T Brogan, et al.
Journal of Medicinal Chemistry
|
April 17, 2014
Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence
Raveendra-Panickar Dhanya, Douglas J Sheffler, Russell Dahl, et al.
Hepatology (Baltimore, Md.)
|
March 30, 2023
Predicting liver-related events in NAFLD: A predictive model
Luis Calzadilla-Bertot, Gary P Jeffrey, Zhengyi Wang, et al.
Journal of Medicinal Chemistry
|
October 30, 2013
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)
Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 15, 2012
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule
Bruce J Melancon, Michael S Poslusney, Patrick R Gentry, et al.
Journal of Medicinal Chemistry
|
October 24, 2018
Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu<sub>2</sub>) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5- a]pyrimidine-5-carboxamide and Thieno[3,2- b]pyridine-5-carboxamide Cores
Elizabeth S Childress, Joshua M Wieting, Andrew S Felts, et al.
Page
of 66
Search research articles
Search
Showing results (511-520 of 651) with videos related to
Sort By:
Page
of 66
ACS Medicinal Chemistry Letters
|
September 28, 2018
VU6007477, a Novel M<sub>1</sub> PAM Based on a Pyrrolo[2,3-<i>b</i>]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events
Julie L Engers, Elizabeth S Childress, Madeline F Long, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|
March 28, 2018
M<sub>1</sub>-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition
Sean P Moran, Jonathan W Dickerson, Hyekyung P Cho, et al.
Hepatology (Baltimore, Md.)
|
September 26, 2020
ABIDE: An Accurate Predictive Model of Liver Decompensation in Patients With Nonalcoholic Fatty Liver-Related Cirrhosis
Luis Calzadilla-Bertot, Eduardo Vilar-Gomez, Vincent Wai-Sun Wong, et al.
Journal of Medicinal Chemistry
|
January 5, 2019
Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu<sub>7</sub> Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1 H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962)
Carson W Reed, Samantha E Yohn, Jordan P Washecheck, et al.
ACS Chemical Biology
|
August 20, 2014
Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics
Hyekyung P Cho, Pedro M Garcia-Barrantes, John T Brogan, et al.
Journal of Medicinal Chemistry
|
April 17, 2014
Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence
Raveendra-Panickar Dhanya, Douglas J Sheffler, Russell Dahl, et al.
Hepatology (Baltimore, Md.)
|
March 30, 2023
Predicting liver-related events in NAFLD: A predictive model
Luis Calzadilla-Bertot, Gary P Jeffrey, Zhengyi Wang, et al.
Journal of Medicinal Chemistry
|
October 30, 2013
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)
Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 15, 2012
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule
Bruce J Melancon, Michael S Poslusney, Patrick R Gentry, et al.
Journal of Medicinal Chemistry
|
October 24, 2018
Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu<sub>2</sub>) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5- a]pyrimidine-5-carboxamide and Thieno[3,2- b]pyridine-5-carboxamide Cores
Elizabeth S Childress, Joshua M Wieting, Andrew S Felts, et al.
Page
of 66