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Bioorganic & Medicinal Chemistry Letters|January 24, 2015
Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacementsAnthony J Roecker, Swati P Mercer, Jeffrey M Bergman, et al.
Brain Research|September 3, 2011
TASK-3 as a potential antidepressant targetAnthony L Gotter, Vincent P Santarelli, Scott M Doran, et al.
Bioorganic & Medicinal Chemistry Letters|May 19, 2015
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development propertiesScott D Kuduk, Jason W Skudlarek, Christina N DiMarco, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|June 1, 2013
Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in ratsSteven V Fox, Anthony L Gotter, Spencer J Tye, et al.
Chemmedchem|September 15, 2011
Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3)Craig A Coburn, Yunfu Luo, Mingxiang Cui, et al.
BMC Neuroscience|August 29, 2013
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy thresholdAnthony L Gotter, Christopher J Winrow, Joseph Brunner, et al.
Scientific Reports|June 4, 2016
Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to ManAnthony L Gotter, Mark S Forman, Charles M Harrell, et al.
Bioorganic & Medicinal Chemistry Letters|January 12, 2015
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexantIzzat T Raheem, Michael J Breslin, Joseph Bruno, et al.
Science Translational Medicine|April 5, 2013
Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognitionJason M Uslaner, Spencer J Tye, Donnie M Eddins, et al.
Bioorganic & Medicinal Chemistry Letters|February 21, 2017
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonistsJason W Skudlarek, Christina N DiMarco, Kerim Babaoglu, et al.
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