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European Journal of Medicinal Chemistry|January 8, 2022
Discovery of novel verinurad analogs as dual inhibitors of URAT1 and GLUT9 with improved Druggability for the treatment of hyperuricemiaZean Zhao, Jin Liu, Peihua Kuang, et al.
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology|May 27, 2021
Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathwayYongmei Li, Zean Zhao, Jian Luo, et al.
Biochemical Pharmacology|October 28, 2023
A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivoYuanxing Zhi, Xiaoyan Wu, Yanshan Chen, et al.
European Journal of Medicinal Chemistry|December 23, 2023
Discovery of a novel anti-osteoporotic agent from marine fungus-derived structurally diverse sireninsJian Cai, Li Gao, Yue Wang, et al.
Pharmacological Research|November 25, 2023
The volume regulated anion channel VRAC regulates NLRP3 inflammasome by modulating itaconate efflux and mitochondria functionXiaoyan Wu, Xin Yi, Boxin Zhao, et al.
ACS Omega|January 6, 2021
Structural Insights into the Atomistic Mechanisms of Uric Acid Recognition and Translocation of Human Urate Anion Transporter 1Ze'an Zhao, Yu Jiang, Lu Li, et al.
Nature Communications|February 24, 2026
VRAC coordinates the trade-off between nutrient absorption and antimicrobial defense in enterocytes against inflammationXin Yi, Shiqing Zhang, Xinpei Gu, et al.
ACS Chemical Neuroscience|April 3, 2019
DCPIB, an Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulates K2P ChannelsJinyan Lv, Yemei Liang, Shiqing Zhang, et al.
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