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ACS Medicinal Chemistry Letters|March 28, 2015
Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) InhibitorsFrederik J R Rombouts, Gary Tresadern, Peter Buijnsters, et al.Journal of Medicinal Chemistry|September 23, 2021
Discovery of Extremely Selective Fused Pyridine-Derived β-Site Amyloid Precursor Protein-Cleaving Enzyme (BACE1) Inhibitors with High In Vivo Efficacy through 10s Loop InteractionsTatsuhiko Ueno, Eriko Matsuoka, Naoya Asada, et al.ACS Medicinal Chemistry Letters|September 16, 2014
Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target EngagementPeter Buijnsters, Meri De Angelis, Xavier Langlois, et al.European Journal of Nuclear Medicine and Molecular Imaging|June 15, 2020
Clinical evaluation of [<sup>18</sup>F] JNJ-64326067, a novel candidate PET tracer for the detection of tau pathology in Alzheimer's diseaseMark E Schmidt, Luc Janssens, Diederik Moechars, et al.European Journal of Medicinal Chemistry|December 17, 2021
Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic studyFrederik J R Rombouts, Chien-Chi Hsiao, Solène Bache, et al.ACS Medicinal Chemistry Letters|January 21, 2022
A Brain-Penetrant and Bioavailable Pyrazolopiperazine BACE1 Inhibitor Elicits Sustained Reduction of Amyloid β In VivoAldo Peschiulli, Daniel Oehlrich, Michiel Van Gool, et al.ACS Omega|June 20, 2017
Fragment Binding to β-Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening ApproachesFrederik J R Rombouts, Richard Alexander, Erna Cleiren, et al.Journal of Medicinal Chemistry|March 15, 2021
Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2Kazuki Fujimoto, Shuhei Yoshida, Genta Tadano, et al.Journal of Medicinal Chemistry|February 28, 2019
Discovery of N-(4-[<sup>18</sup>F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging TracerFrederik J R Rombouts, Lieven Declercq, José-Ignacio Andrés, et al.Bioorganic & Medicinal Chemistry Letters|July 30, 2013
Design and synthesis of bicyclic heterocycles as potent γ-secretase modulatorsDaniel Oehlrich, Frederik J R Rombouts, Didier Berthelot, et al.Pageof 3