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Bioorganic & Medicinal Chemistry Letters|May 31, 2011
Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stabilityQingsong Liu, Jinhua Wang, Seong A Kang, et al.
The Journal of Biological Chemistry|January 20, 2009
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1Carson C Thoreen, Seong A Kang, Jae Won Chang, et al.
Journal of Medicinal Chemistry|September 24, 2010
Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancerQingsong Liu, Jae Won Chang, Jinhua Wang, et al.
Methods in Molecular Biology (Clifton, N.J.)|November 30, 2011
Development of ATP-competitive mTOR inhibitorsQingsong Liu, Seong A Kang, Carson C Thoreen, et al.
Science (New York, N.Y.)|July 27, 2013
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycinSeong A Kang, Michael E Pacold, Christopher L Cervantes, et al.
Cancer Research|December 4, 2016
ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAPTaru Muranen, Laura M Selfors, Julie Hwang, et al.
Cell Chemical Biology|June 25, 2019
Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose TransportersSeong A Kang, David J O'Neill, Andreas W Machl, et al.
Cell|August 6, 2011
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathwayTimothy R Peterson, Shomit S Sengupta, Thurl E Harris, et al.
Science (New York, N.Y.)|June 11, 2011
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signalingPeggy P Hsu, Seong A Kang, Jonathan Rameseder, et al.
The Journal of Biological Chemistry|January 7, 2012
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kineticsQingsong Liu, Sivapriya Kirubakaran, Wooyoung Hur, et al.
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