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Sergio C Chai

Showing results (41-50 of 51) with videos related to

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Biochemical Pharmacology|June 30, 2015
Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivoYue-Ming Wang, Sergio C Chai, Wenwei Lin, et al.
ACS Medicinal Chemistry Letters|June 25, 2025
HTS Identifies NUP98-KDM5A-PHD3 Domain Ligands with Novel ScaffoldsWenwei Lin, P Jake Slavish, Aaron H Phillips, et al.
ACS Medicinal Chemistry Letters|October 18, 2023
Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule InhibitorsCaroline R Buchholz, Molly S Sneddon, Joseph E McPherson, et al.
Analytical Chemistry|April 17, 2026
Label-Free High-Throughput Screening of CYP3A4 Inhibitors Using Acoustic Ejection Mass SpectrometryMary Ashley Rimmer, Jingheng Wang, Tharindu A Ranathunge, et al.
Molecular Cell|February 22, 2023
E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelityDaniel C Scott, Moeko T King, Kheewoong Baek, et al.
Nucleic Acids Research|February 25, 2022
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulationMonicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, et al.
European Journal of Medicinal Chemistry|March 10, 2023
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitorsMladen Koravovic, Anand Mayasundari, Gordana Tasic, et al.
Bioorganic & Medicinal Chemistry|November 25, 2017
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitorsWilliam R Shadrick, Peter J Slavish, Sergio C Chai, et al.
Nature Communications|October 12, 2024
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2Daniel C Scott, Suresh Dharuman, Elizabeth Griffith, et al.
Nature Chemical Biology|June 6, 2017
Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligaseDaniel C Scott, Jared T Hammill, Jaeki Min, et al.
Pageof 6

Showing results (41-50 of 51) with videos related to

Sort By:
Pageof 6
Biochemical Pharmacology|June 30, 2015
Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivoYue-Ming Wang, Sergio C Chai, Wenwei Lin, et al.
ACS Medicinal Chemistry Letters|June 25, 2025
HTS Identifies NUP98-KDM5A-PHD3 Domain Ligands with Novel ScaffoldsWenwei Lin, P Jake Slavish, Aaron H Phillips, et al.
ACS Medicinal Chemistry Letters|October 18, 2023
Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule InhibitorsCaroline R Buchholz, Molly S Sneddon, Joseph E McPherson, et al.
Analytical Chemistry|April 17, 2026
Label-Free High-Throughput Screening of CYP3A4 Inhibitors Using Acoustic Ejection Mass SpectrometryMary Ashley Rimmer, Jingheng Wang, Tharindu A Ranathunge, et al.
Molecular Cell|February 22, 2023
E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelityDaniel C Scott, Moeko T King, Kheewoong Baek, et al.
Nucleic Acids Research|February 25, 2022
Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulationMonicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, et al.
European Journal of Medicinal Chemistry|March 10, 2023
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitorsMladen Koravovic, Anand Mayasundari, Gordana Tasic, et al.
Bioorganic & Medicinal Chemistry|November 25, 2017
Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitorsWilliam R Shadrick, Peter J Slavish, Sergio C Chai, et al.
Nature Communications|October 12, 2024
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2Daniel C Scott, Suresh Dharuman, Elizabeth Griffith, et al.
Nature Chemical Biology|June 6, 2017
Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligaseDaniel C Scott, Jared T Hammill, Jaeki Min, et al.
Pageof 6