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FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology|November 22, 2014
Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemiaVioleta Gomez-Rodriguez, Josune Orbe, Esther Martinez-Aguilar, et al.
Proceedings of the National Academy of Sciences of the United States of America|July 16, 2008
Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatmentT Dejaegere, L Serneels, M K Schäfer, et al.
The Journal of Pharmacology and Experimental Therapeutics|September 27, 2007
1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicityBruno P Imbimbo, Elda Del Giudice, Davide Colavito, et al.
Nature Communications|November 29, 2024
Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer's disease-relevant brain circuitsAnika Perdok, Zoë P Van Acker, Céline Vrancx, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|April 30, 2002
Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic miceIlse Dewachter, Delphine Reversé, Nathalie Caluwaerts, et al.
The Journal of Biological Chemistry|May 10, 2023
Selective inhibitors of the PSEN1-gamma-secretase complexLutgarde Serneels, Rajeshwar Narlawar, Laura Perez-Benito, et al.
Molecular Cell|November 17, 2023
The γ-secretase substrate proteome and its role in cell signaling regulationPengfei Hou, Magdalena Zielonka, Lutgarde Serneels, et al.
Proceedings of the National Academy of Sciences of the United States of America|December 23, 2018
PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndromeMarco Spinazzi, Enrico Radaelli, Katrien Horré, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|April 8, 2010
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortexEllen Jorissen, Johannes Prox, Christian Bernreuther, et al.
Neuron|February 22, 2005
Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disordersMarcel W Coolen, Karen M J Van Loo, Nick N H M Van Bakel, et al.
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