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ACS Chemical Biology|April 16, 2016
Discovery of a Highly Selective STK16 Kinase InhibitorFeiyang Liu, Jinhua Wang, Xingxing Yang, et al.
CNS Neuroscience & Therapeutics|July 1, 2020
Retracted: Allopregnanolone restores the tyrosine hydroxylase-positive neurons and motor performance in a 6-OHDA-injected mouse modelZhi-Chi Chen, Tong-Tong Wang, Wei Bian, et al.
Journal of Medicinal Chemistry|June 29, 2019
Discovery of 2-(4-Chloro-3-(trifluoromethyl)phenyl)-N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)acetamide (CHMFL-KIT-64) as a Novel Orally Available Potent Inhibitor against Broad-Spectrum Mutants of c-KIT Kinase for Gastrointestinal Stromal TumorsYun Wu, Beilei Wang, Junjie Wang, et al.
Journal of Medicinal Chemistry|December 15, 2016
Discovery of 4-Methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-yl)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge BindingQiang Wang, Feiyang Liu, Beilei Wang, et al.
Acta Pharmacologica Sinica|March 1, 2022
CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancersJiang-Yan Cao, Shuang Qi, Hong Wu, et al.
European Journal of Medicinal Chemistry|March 16, 2018
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemiaQiang Wang, Feiyang Liu, Shuang Qi, et al.
Cancer Letters|January 27, 2019
Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical modelsTingting Lu, Cheng Chen, Aoli Wang, et al.
Acta Pharmacologica Sinica|May 14, 2020
Osimertinib successfully combats EGFR-negative glioblastoma cells by inhibiting the MAPK pathwayCheng Chen, Chuan-Dong Cheng, Hong Wu, et al.
Biological Psychiatry|November 21, 2018
Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of BenzodiazepineZu-Cheng Shen, Peng-Fei Wu, Fang Wang, et al.
Open Biology|September 8, 2017
The rapid in vivo evolution of Pseudomonas aeruginosa in ventilator-associated pneumonia patients leads to attenuated virulenceKe Wang, Yi-Qiang Chen, May M Salido, et al.
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