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Bioorganic & Medicinal Chemistry Letters|August 4, 2012
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibitionAlexander G Dossetter, Jonathan Bowyer, Calum R Cook, et al.Bioorganic & Medicinal Chemistry Letters|June 12, 2009
Dipeptidyl nitrile inhibitors of Cathepsin LNabil Asaad, Paul A Bethel, Michelle D Coulson, et al.Bioorganic & Medicinal Chemistry|June 6, 2021
Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistryJohn P Guilinger, Archna Archna, Martin Augustin, et al.Journal of Medicinal Chemistry|September 19, 2012
Pharmacokinetic benefits of 3,4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitorsJames J Crawford, Peter W Kenny, Jonathan Bowyer, et al.Journal of Medicinal Chemistry|June 30, 2012
(1R,2R)-N-(1-cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): a potent and highly selective cathepsin K inhibitor for the treatment of osteoarthritisAlexander G Dossetter, Howard Beeley, Jonathan Bowyer, et al.Journal of Medicinal Chemistry|July 22, 2021
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) ApoenzymeMatthew M Hamilton, Faika Mseeh, Timothy J McAfoos, et al.Pageof 2