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Medchemcomm|October 18, 2016
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9Carl S Rye, Nicola E A Chessum, Scott Lamont, et al.Journal of Medicinal Chemistry|April 5, 2023
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other MalignanciesA Elisa Pasqua, Swee Y Sharp, Nicola E A Chessum, et al.Molecular Cancer Therapeutics|April 14, 2007
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analoguesSwee Y Sharp, Chrisostomos Prodromou, Kathy Boxall, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|July 12, 2012
AT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activityTimothy A Yap, Mike I Walton, Kyla M Grimshaw, et al.Journal of Medicinal Chemistry|January 23, 2016
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19Aurélie Mallinger, Kai Schiemann, Christian Rink, et al.Journal of Medicinal Chemistry|December 23, 2016
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic ScreenMatthew D Cheeseman, Nicola E A Chessum, Carl S Rye, et al.Nature Reviews. Clinical Oncology|February 9, 2019
Challenges to curing primary brain tumoursKenneth Aldape, Kevin M Brindle, Louis Chesler, et al.Gut|September 14, 2016
Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancersPietro Carotenuto, Matteo Fassan, Rosantony Pandolfo, et al.Nature Chemical Biology|October 27, 2015
A selective chemical probe for exploring the role of CDK8 and CDK19 in human diseaseTrevor Dale, Paul A Clarke, Christina Esdar, et al.Gastroenterology|November 9, 2017
MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in CholangiocarcinomaAndrea Lampis, Pietro Carotenuto, Georgios Vlachogiannis, et al.Pageof 37