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Elife|December 10, 2016
Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinasesPaul A Clarke, Maria-Jesus Ortiz-Ruiz, Robert TePoele, et al.Journal of Medicinal Chemistry|February 14, 2015
Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screenAurélie Mallinger, Simon Crumpler, Mark Pichowicz, et al.Journal of Medicinal Chemistry|July 21, 2009
Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperonePaul A Brough, Xavier Barril, Jenifer Borgognoni, et al.Hepatology (Baltimore, Md.)|December 28, 2019
Modulation of Biliary Cancer Chemo-Resistance Through MicroRNA-Mediated Rewiring of the Expansion of CD133+ CellsPietro Carotenuto, Somaieh Hedayat, Matteo Fassan, et al.Nature Medicine|January 22, 2019
Small-molecule targeting of brachyury transcription factor addiction in chordomaTanaz Sharifnia, Mathias J Wawer, Ting Chen, et al.Journal of Medicinal Chemistry|August 30, 2008
The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancerAdrian J Folkes, Khatereh Ahmadi, Wendy K Alderton, et al.Cancer Research|April 17, 2008
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasisSuzanne A Eccles, Andy Massey, Florence I Raynaud, et al.Nature Communications|November 19, 2021
Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damagePietro Carotenuto, Francesco Amato, Andrea Lampis, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|January 9, 2025
NXP800 Activates the Unfolded Protein Response, Altering AR and E2F Function to Impact Castration-Resistant Prostate Cancer GrowthJonathan Welti, Denisa Bogdan, Ines Figueiredo, et al.Journal of Medicinal Chemistry|November 21, 2007
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancerPaul A Brough, Wynne Aherne, Xavier Barril, et al.Pageof 37