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Tim J Wigle

Showing results (11-20 of 37) with videos related to

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FEBS Letters|August 23, 2011
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation statesTim J Wigle, Sarah K Knutson, Lei Jin, et al.
The Biochemical Journal|May 18, 2013
Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSETBrooke M Swalm, Kenneth K Hallenbeck, Christina R Majer, et al.
Current Chemical Genomics|July 22, 2010
Novel Inhibitors of E. coli RecA ATPase ActivityJonathan Z Sexton, Tim J Wigle, Qingping He, et al.
Journal of Biomolecular Screening|August 14, 2009
Inhibitors of RecA activity discovered by high-throughput screening: cell-permeable small molecules attenuate the SOS response in Escherichia coliTim J Wigle, Jonathan Z Sexton, Anna V Gromova, et al.
Biochemistry|January 28, 2016
Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IPAravind Basavapathruni, Jodi Gureasko, Margaret Porter Scott, et al.
FEBS Letters|August 2, 2012
A687V EZH2 is a gain-of-function mutation found in lymphoma patientsChristina R Majer, Lei Jin, Margaret Porter Scott, et al.
SLAS Discovery : Advancing Life Sciences R & D|December 20, 2019
Forced Self-Modification Assays as a Strategy to Screen MonoPARP EnzymesTim J Wigle, W David Church, Christina R Majer, et al.
ACS Chemical Biology|August 26, 2014
Reaction coupling between wild-type and disease-associated mutant EZH2Brooke M Swalm, Sarah K Knutson, Natalie M Warholic, et al.
Journal of Biomolecular Screening|March 11, 2015
A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase ScreeningTim J Wigle, Kerren K Swinger, John E Campbell, et al.
Proceedings of the National Academy of Sciences of the United States of America|April 27, 2013
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2Sarah K Knutson, Natalie M Warholic, Tim J Wigle, et al.
Pageof 4

Showing results (11-20 of 37) with videos related to

Sort By:
Pageof 4
FEBS Letters|August 23, 2011
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation statesTim J Wigle, Sarah K Knutson, Lei Jin, et al.
The Biochemical Journal|May 18, 2013
Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSETBrooke M Swalm, Kenneth K Hallenbeck, Christina R Majer, et al.
Current Chemical Genomics|July 22, 2010
Novel Inhibitors of E. coli RecA ATPase ActivityJonathan Z Sexton, Tim J Wigle, Qingping He, et al.
Journal of Biomolecular Screening|August 14, 2009
Inhibitors of RecA activity discovered by high-throughput screening: cell-permeable small molecules attenuate the SOS response in Escherichia coliTim J Wigle, Jonathan Z Sexton, Anna V Gromova, et al.
Biochemistry|January 28, 2016
Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IPAravind Basavapathruni, Jodi Gureasko, Margaret Porter Scott, et al.
FEBS Letters|August 2, 2012
A687V EZH2 is a gain-of-function mutation found in lymphoma patientsChristina R Majer, Lei Jin, Margaret Porter Scott, et al.
SLAS Discovery : Advancing Life Sciences R & D|December 20, 2019
Forced Self-Modification Assays as a Strategy to Screen MonoPARP EnzymesTim J Wigle, W David Church, Christina R Majer, et al.
ACS Chemical Biology|August 26, 2014
Reaction coupling between wild-type and disease-associated mutant EZH2Brooke M Swalm, Sarah K Knutson, Natalie M Warholic, et al.
Journal of Biomolecular Screening|March 11, 2015
A High-Throughput Mass Spectrometry Assay Coupled with Redox Activity Testing Reduces Artifacts and False Positives in Lysine Demethylase ScreeningTim J Wigle, Kerren K Swinger, John E Campbell, et al.
Proceedings of the National Academy of Sciences of the United States of America|April 27, 2013
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2Sarah K Knutson, Natalie M Warholic, Tim J Wigle, et al.
Pageof 4