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Journal of Medicinal Chemistry
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November 20, 2018
Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae
Laura Friggeri, Tatiana Y Hargrove, Girish Rachakonda, et al.
Investigative Ophthalmology & Visual Science
|
November 10, 2021
Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model
Jessica V Kaczmarek, Carley M Bogan, Janene M Pierce, et al.
Journal of Medicinal Chemistry
|
October 30, 2013
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)
Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 15, 2012
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule
Bruce J Melancon, Michael S Poslusney, Patrick R Gentry, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 17, 2009
Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators
Feng V Yang, William D Shipe, Jaime L Bunda, et al.
Journal of Medicinal Chemistry
|
October 24, 2018
Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu<sub>2</sub>) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5- a]pyrimidine-5-carboxamide and Thieno[3,2- b]pyridine-5-carboxamide Cores
Elizabeth S Childress, Joshua M Wieting, Andrew S Felts, et al.
Neuron
|
September 13, 2016
Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release
Daniel J Foster, Jermaine M Wilson, Daniel H Remke, et al.
Bioorganic & Medicinal Chemistry Letters
|
September 21, 2019
Discovery of a novel 3,4-dimethylcinnoline carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotype via scaffold hopping
Kayla J Temple, Julie L Engers, Madeline F Long, et al.
Genes, Brain, and Behavior
|
April 6, 2020
Phenotypic profiling of mGlu<sub>7</sub> knockout mice reveals new implications for neurodevelopmental disorders
Nicole M Fisher, Robert W Gould, Rocco G Gogliotti, et al.
ACS Chemical Neuroscience
|
July 22, 2016
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers
Colleen M Niswender, Carrie K Jones, Xin Lin, et al.
Page
of 57
Search research articles
Search
Showing results (421-430 of 570) with videos related to
Sort By:
Page
of 57
Journal of Medicinal Chemistry
|
November 20, 2018
Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae
Laura Friggeri, Tatiana Y Hargrove, Girish Rachakonda, et al.
Investigative Ophthalmology & Visual Science
|
November 10, 2021
Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model
Jessica V Kaczmarek, Carley M Bogan, Janene M Pierce, et al.
Journal of Medicinal Chemistry
|
October 30, 2013
Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375)
Patrick R Gentry, Masaya Kokubo, Thomas M Bridges, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 15, 2012
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule
Bruce J Melancon, Michael S Poslusney, Patrick R Gentry, et al.
Bioorganic & Medicinal Chemistry Letters
|
December 17, 2009
Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators
Feng V Yang, William D Shipe, Jaime L Bunda, et al.
Journal of Medicinal Chemistry
|
October 24, 2018
Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu<sub>2</sub>) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5- a]pyrimidine-5-carboxamide and Thieno[3,2- b]pyridine-5-carboxamide Cores
Elizabeth S Childress, Joshua M Wieting, Andrew S Felts, et al.
Neuron
|
September 13, 2016
Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release
Daniel J Foster, Jermaine M Wilson, Daniel H Remke, et al.
Bioorganic & Medicinal Chemistry Letters
|
September 21, 2019
Discovery of a novel 3,4-dimethylcinnoline carboxamide M<sub>4</sub> positive allosteric modulator (PAM) chemotype via scaffold hopping
Kayla J Temple, Julie L Engers, Madeline F Long, et al.
Genes, Brain, and Behavior
|
April 6, 2020
Phenotypic profiling of mGlu<sub>7</sub> knockout mice reveals new implications for neurodevelopmental disorders
Nicole M Fisher, Robert W Gould, Rocco G Gogliotti, et al.
ACS Chemical Neuroscience
|
July 22, 2016
Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers
Colleen M Niswender, Carrie K Jones, Xin Lin, et al.
Page
of 57