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Neuron|January 19, 2022
Acute restraint stress redirects prefrontal cortex circuit function through mGlu<sub>5</sub> receptor plasticity on somatostatin-expressing interneuronsMax E Joffe, James Maksymetz, Joseph R Luschinger, et al.
Bioorganic & Medicinal Chemistry Letters|December 13, 2016
Challenges in the development of an M<sub>4</sub> PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogsMichael R Wood, Meredith J Noetzel, Michael S Poslusney, et al.
Assay and Drug Development Technologies|April 6, 2017
Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human GeneticsJill M Pulley, Jana K Shirey-Rice, Robert R Lavieri, et al.
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology|August 29, 2015
Partial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like EffectsRobert W Gould, Russell J Amato, Michael Bubser, et al.
Journal of Medicinal Chemistry|May 23, 2017
Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical EvaluationAndrew S Felts, Alice L Rodriguez, Anna L Blobaum, et al.
Bioorganic & Medicinal Chemistry Letters|April 27, 2017
Optimization of M<sub>4</sub> positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacologyBruce J Melancon, Michael R Wood, Meredith J Noetzel, et al.
ACS Chemical Neuroscience|April 22, 2018
Discovery and Optimization of Potent and CNS Penetrant M<sub>5</sub>-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide ScaffoldAaron M Bender, Hyekyung P Cho, Kellie D Nance, et al.
ACS Chemical Neuroscience|July 7, 2026
Discovery of VU6077564: A Selective M<sub>1</sub> Antagonist That Promotes Neurite Outgrowth in Adult Sensory NeuronsTomayo I Berida, Cayden J Dodd, Joshua C Wilkinson, et al.
Molecular Pharmacology|October 7, 2010
Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activityAlice L Rodriguez, Mark D Grier, Carrie K Jones, et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience|November 13, 2009
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learningJana K Shirey, Ashley E Brady, Paulianda J Jones, et al.
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