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European Journal of Medicinal Chemistry|May 26, 2021
UNC5293, a potent, orally available and highly MERTK-selective inhibitorHongchao Zheng, Jichen Zhao, Bing Li, et al.ACS Medicinal Chemistry Letters|December 21, 2016
Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase InhibitorsXiaodong Wang, Jing Liu, Weihe Zhang, et al.Journal of Medicinal Chemistry|August 26, 2021
Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE)Pravin L Kotian, Minwan Wu, Satish Vadlakonda, et al.Chemmedchem|December 30, 2016
Discovery of Macrocyclic Pyrimidines as MerTK-Specific InhibitorsAndrew L McIver, Weihe Zhang, Qingyang Liu, et al.Proceedings of the National Academy of Sciences of the United States of America|July 27, 2019
Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphomaJason P Wong, Timothy J Stuhlmiller, Louise C Giffin, et al.Clinical Cancer Research : an Official Journal of the American Association for Cancer Research|September 21, 2016
UNC2025, a MERTK Small-Molecule Inhibitor, Is Therapeutically Effective Alone and in Combination with Methotrexate in Leukemia ModelsDeborah DeRyckere, Alisa B Lee-Sherick, Madeline G Huey, et al.Journal of Medicinal Chemistry|October 23, 2018
Highly Selective MERTK Inhibitors Achieved by a Single Methyl GroupJichen Zhao, Dehui Zhang, Weihe Zhang, et al.Oncotarget|March 13, 2015
Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemiaAlisa B Lee-Sherick, Weihe Zhang, Kelly K Menachof, et al.Journal of Medicinal Chemistry|July 29, 2014
UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitorWeihe Zhang, Deborah DeRyckere, Debra Hunter, et al.European Journal of Medicinal Chemistry|May 23, 2013
UNC1062, a new and potent Mer inhibitorJing Liu, Weihe Zhang, Michael A Stashko, et al.Pageof 7