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CPT: Pharmacometrics & Systems Pharmacology|November 12, 2024
Local depletion of large molecule drugs due to target binding in tissue interstitial spaceTatiana Zasedateleva, Stephan Schaller, Elizabeth C M de Lange, et al.Trends in Pharmacological Sciences|July 11, 2016
In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as DeterminantWilhelmus E A de Witte, Meindert Danhof, Piet H van der Graaf, et al.Expert Opinion on Drug Discovery|September 22, 2017
Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamicsElizabeth C M de Lange, Willem van den Brink, Yumi Yamamoto, et al.CPT: Pharmacometrics & Systems Pharmacology|July 4, 2025
Prediction of a CLDN18.2 Targeted Antibody Drug Conjugate Pharmacokinetics in Cancer Patients Using PBPK Modeling and SimulationChiara Zunino, Sichen Wang, Yanyan Zhang, et al.Journal of Pharmacokinetics and Pharmacodynamics|March 6, 2023
Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large moleculesWilhelmus E A de Witte, Lindsay B Avery, Brian C Mackness, et al.Journal of Pharmacokinetics and Pharmacodynamics|September 2, 2018
Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment modelsWilhelmus E A de Witte, Vivi Rottschäfer, Meindert Danhof, et al.Drug Delivery and Translational Research|October 10, 2025
From simulation to application: enhancing preclinical evaluation of dissolvable microarray patches through PBPK modellingMaja Railic, Wilhelmus E A de Witte, Stephan Schaller, et al.Journal of Pharmacokinetics and Pharmacodynamics|May 20, 2018
Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment modelsWilhelmus E A de Witte, Vivi Rottschäfer, Meindert Danhof, et al.The AAPS Journal|December 6, 2017
Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity ModelingAnna H C Vlot, Wilhelmus E A de Witte, Meindert Danhof, et al.Pharmaceutics|January 28, 2026
Correction: Susilo et al. Whole-Body Physiologically Based Pharmacokinetic Modeling Framework for Tissue Target Engagement of CD3 Bispecific Antibodies. Pharmaceutics 2025, 17, 500Monica E Susilo, Stephan Schaller, Luis David Jiménez-Franco, et al.Pageof 2