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Journal of Medicinal Chemistry|October 3, 2022
Discovery of 2-Methyl-2-(4-(2-methyl-8-(1<i>H</i>-pyrrolo[2,3-<i>b</i>]pyridin-6-yl)-1<i>H</i>-naphtho[1,2-<i>d</i>]imidazol-1-yl)phenyl)propanenitrile as a Novel PI3K/mTOR Inhibitor with Enhanced Antitumor Efficacy <i>In Vitro</i> and <i>In Vivo</i>Jie Yang, Yuanyuan Liu, Suke Lan, et al.
European Journal of Medicinal Chemistry|June 23, 2019
Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and orally active PI3K/mTOR dual inhibitorsGuoyi Yan, Chunlan Pu, Suke Lan, et al.
Anti-Cancer Agents in Medicinal Chemistry|January 29, 2021
Design, Synthesis and Biological Evaluation of 4, 6-Coumarin Derivatives as Anti- Cancer and Apoptosis-Inducing AgentsGuoyi Yan, Jiang Luo, Xuan Han, et al.
European Journal of Medicinal Chemistry|May 11, 2020
Discovery of 4-(3,5-dimethoxy-4-(((4-methoxyphenethyl)amino)methyl)phenoxy)-N-phenylaniline as a novel c-myc inhibitor against colorectal cancer in vitro and in vivoJie Yang, Chaoguo Cao, Dan Luo, et al.
Molecular Therapy. Nucleic Acids|April 11, 2022
The Aptamer Ob2, a novel AChE inhibitor, restores cognitive deficits and alleviates amyloidogenesis in 5×FAD transgenic miceZhiman Liang, Xin Li, Xiaoting Luo, et al.
European Journal of Medicinal Chemistry|April 15, 2021
Discovery of a novel covalent CDK4/6 inhibitor based on palbociclib scaffoldHuifang Shan, Xinyu Ma, Guoyi Yan, et al.
Journal of Ethnopharmacology|November 9, 2025
Scutellarin alleviates ferroptosis in cigarette smoke-induced chronic obstructive pulmonary disease via activation of the PI3K/AKT/Nrf2 signaling pathwayKai Ding, Xiaowen He, Yi Gou, et al.
Journal of Ginseng Research|November 25, 2024
Ginsenoside Rg1 reduces cardiac inflammation against myocardial ischemia/reperfusion injury by inhibiting macrophage polarizationXiaojin Xu, Qing Wu, Ke Pei, et al.
BMC Infectious Diseases|May 1, 2026
Explainable prediction of MDR/RR-TB in tuberculosis-diabetes mellitus multimorbidity: a machine learning model developed and validated in a dual-center studyXinxin Zhong, Kuan Liu, Jiujin Zhang, et al.
European Journal of Medicinal Chemistry|July 10, 2021
Lead optimization to improve the antiviral potency of 2-aminobenzamide derivatives targeting HIV-1 Vif-A3G axisXinxin Zhong, Ronghua Luo, Guoyi Yan, et al.
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