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Bioorganic Chemistry|December 9, 2025
Aucubin attenuates neonatal hypoxic-ischemic brain injury by suppressing NLRP3 inflammasome-mediated microglial pyroptosisHaidi Bi, Kai Le, Qi Xiong, et al.
Bioorganic Chemistry|December 7, 2025
Disulfide-bonded YC18: A membrane-targeting peptide with superior efficacy against Staphylococcus aureus infectionsJinai Gao, Yi Wang, Wanting Wang, et al.
Bioorganic Chemistry|November 19, 2025
Synthesis, carbonic anhydrase inhibition and in silico insights of 4-formyl-2-nitrophenyl naphthalene-2-sulfonate hybrid thiosemicarbazonesKhawar Abbas, Muhammad Islam, Muhammad Tayyab, et al.
Bioorganic Chemistry|November 18, 2025
Methylcarvones as immunomodulators through antagonism of aryl hydrocarbon receptorIveta Zůvalová, Aneta Grycová, Jiří Hrubý, et al.
Bioorganic Chemistry|November 18, 2025
Discovery of novel aniline-pyrimidine analogues as orally bioavailable dual VEGFR-2/tubulin inhibitors with potent antitumor and anti-angiogenesis efficacyYanan Chu, Guiyan Huang, Yongfang Yao, et al.
Bioorganic Chemistry|November 27, 2025
Cavity engineering-driven switching of cofactor specificity in a carbonyl reductase for the synthesis of chiral aryl β-Hydroxy α-amino acidJiawei Tang, Jirui Zhong, Hao Chen, et al.
Bioorganic Chemistry|December 3, 2025
Design and synthesis of a 1,3,6-trimethyl-1H-benzo[d]imidazole-5-sulfonamide derivative as a type I CDK8 inhibitor against colorectal cancerJuncheng Du, Yu Zhang, Daxing Shi, et al.
Bioorganic Chemistry|December 1, 2025
Transient adducts of CO2 with nucleophiles enhance rates of enzymic decarboxylationJerry Augustine, Marc Alexander Zambri, Ronald Kluger
Bioorganic Chemistry|December 3, 2025
Novel bis(triazole) analogues as selective TGR5 agonists with anti-diabesity effectsAnchal Saxena, Devanshu Kaushik, Boda Arun Kumar, et al.
Bioorganic Chemistry|November 30, 2025
Structure-enabled discovery of carboxylate esters prodrugs as potential potent inhibitors targeting Glutaminase CHanyu Sun, Shize Li, Chengxia Mao, et al.
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