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Science Translational Medicine|December 24, 2025
HDAC5 deacetylates cytosolic ACTN4 during skin reepithelialization and represents a therapeutic target for chronic wound healingYifan Zhang, Dongsheng Wen, Chiakang Ho, et al.Science Translational Medicine|December 24, 2025
Targeting brain hubs of ictal fast ripple activity to reduce seizures in patients with drug-resistant epilepsyShanshan Liang, Lukang Wang, Kaifeng Shen, et al.Science Translational Medicine|December 17, 2025
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotectiveAmit Manhas, Yu Liu, Chikage Noishiki, et al.Science Translational Medicine|October 29, 2025
Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft modelsXin Du, Pei K Goh, Chenkai Ma, et al.Science Translational Medicine|October 29, 2025
The IL-33 and IL-4Rα blocking antibodies itepekimab and dupilumab modulate both distinct and common inflammatory mediators in asthmaSeblewongel Asrat, Wei Keat Lim, Subhashini Srivatsan, et al.Science Translational Medicine|July 2, 2025
Targeting HBV with RNA interference: Paths to cureMatteo Iannacone, Cristian G Beccaria, Lena Allweiss, et al.Science Translational Medicine|July 9, 2025
Neuronal HDAC3 knockdown promotes propriospinal detour pathway formation and locomotor recovery in a mouse model of spinal cord injuryZhongyang Gao, Hongyuan Xing, Yifan Shen, et al.Science Translational Medicine|June 25, 2025
Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosusRithwik Narendra, Hoang Van Phan, Sarah L Patterson, et al.Science Translational Medicine|September 17, 2025
Sex differences in HIV-1 reservoir cell selection are linked to altered innate immune profilesToong Seng Tan, Ce Gao, Alexander S Hochroth, et al.Science Translational Medicine|September 24, 2025
Retinal polyunsaturated fatty acid supplementation reverses aging-related vision decline in miceFangyuan Gao, Emily Tom, Cezary Rydz, et al.Pageof 482