Jacob T Bush

22PUBLICATIONS
113CO-AUTHORS
Main group metal chemistryPharmaceutical delivery technologiesCheminformatics and quantitative structure-activity relationshipsCharacterisation of biological macromoleculesBiomolecular modelling and design
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Journal

Publications (22)

|Jul 10, 2026
Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery.

|Jun 01, 2026
Druggability is not static.

|Nov 06, 2025
Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2.

Cassandra R Kennedy, Katherine A McPhie, Aini Vuorinen

|May 14, 2025
Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination.

Katherine A McPhie, Diego Esposito, Jonathan Pettinger

|Jan 14, 2025
Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation.

Aini Vuorinen, Cassandra R Kennedy, Katherine A McPhie

|Jan 02, 2025
Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics.

George S Biggs, Emma E Cawood, Aini Vuorinen

Pageof 4

Frequent Collaborators

10 joint publications

David House

6 joint publications

Katrin Rittinger

5 joint publications

Nicholas C O Tomkinson

4 joint publications

Harry Wilders