David E Shaw
27PUBLICATIONS
109CO-AUTHORS
Get your video featured.
Publish with JoVEGet your video featured.
Publish with JoVE
Publications (27)
Sort by Publication Date:
|Feb 01, 2024
Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.Heike Schönherr, Pelin Ayaz, Alexander M Taylor
|Nov 02, 2023
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.Andreas Varkaris, Ermira Pazolli, Hakan Gunaydin
|Sep 29, 2023
Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors.Alexander M Taylor, Bret R Williams, Fabrizio Giordanetto
|Jun 28, 2023
A Conserved Local Structural Motif Controls the Kinetics of PTP1B Catalysis.Christine Y Yeh, Jesus A Izaguirre, Jack B Greisman
|Jun 04, 2023
RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.Vivek Subbiah, Vaibhav Sahai, Dejan Maglic
|Apr 22, 2023
Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography.Jack B Greisman, Lindsay Willmore, Christine Y Yeh
Pageof 5
Frequent Collaborators
5 joint publications
Fabrizio Giordanetto
3 joint publications
Jack B Greisman
3 joint publications
Roberto Valverde
3 joint publications
Yibing Shan
2 joint publications
Maxwell R Tucker
2 joint publications
Christine Y Yeh
2 joint publications
Seth A Darst
2 joint publications
Edward T Eng
2 joint publications
Brandon Malone
2 joint publications
James Chen
