Kathleen A Farley

12PUBLICATIONS
51CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsCharacterisation of biological macromoleculesComputational chemistryCrystallographyMolecular targets
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Publications (12)

|Feb 28, 2025
Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease.

Jamison B Tuttle, Christophe Allais, Charlotte M N Allerton

|Feb 17, 2025
Conformational Role of Methyl in the Potency of Cyclohexane-Substituted Squaramide CCR6 Antagonists.

Brian S Gerstenberger, Ray Unwalla, Kathleen A Farley

|Nov 20, 2024
Cyclic Peptide C5aR1 Antagonist Design Using Solution Conformational Analysis Derived from Residual Dipolar Couplings.

Kathleen A Farley, Ye Che, Ricardo Lira

|Sep 18, 2024
An Automated Purification Workflow Coupled with Material-Sparing High-Throughput 1H NMR for Parallel Medicinal Chemistry.

Justin Bellenger, Martin R M Koos, Melissa Avery

|Aug 31, 2024
Structural basis for CCR6 modulation by allosteric antagonists.

David Jonathan Wasilko, Brian S Gerstenberger, Kathleen A Farley

|Apr 30, 2024
A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.

Charlotte M N Allerton, Joel T Arcari, Lisa M Aschenbrenner

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