Jan Kubeš

4PUBLICATIONS
28CO-AUTHORS
Haematological tumoursMolecular targetsCancer therapy (excl. chemotherapy and radiation therapy)
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Publications (4)

|Jul 23, 2026
Analysis of gene expression changes upon topobexin treatment and TOP2B-knockout in hiPSC-derived cardiomyocytes.

|May 27, 2025
Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.

Jan Kubeš, Galina Karabanovich, Anh T Q Cong

|Sep 23, 2021
Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation.

Eduard Jirkovský, Anna Jirkovská, Hana Bavlovič-Piskáčková

|Apr 08, 2020
Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase IIβ Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity.

Petra Kollárová-Brázdová, Anna Jirkovská, Galina Karabanovich

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Frequent Collaborators

4 joint publications

Petra Štěrbová-Kovaříková

3 joint publications

Anna Jirkovská

3 joint publications

Galina Karabanovich

3 joint publications

Hana Bavlovič-Piskáčková