Sigal Saphier

9PUBLICATIONS
19CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsBiologically active moleculesBiomolecular modelling and designF-block chemistryBasic pharmacology
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Publications (9)

|Feb 12, 2026
From NH+ Chemical Shifts to Chemical Insights: A 1H NMR Spectroscopic Window into Amine pKa, Anion pKBHX, and Charge-Assisted Intramolecular H-Bond Assessment from a Medicinal Chemistry Perspective.

Shlomi Elias, Dafna Amir, Boris Smolkin

|Jul 16, 2024
Addressing the Opioids Lipophilicity Challenge via a Straightforward and Simultaneous 1H NMR-Based logP/D Determination, Both Separately and in Mixtures.

Dina Yeffet, Ishay Columbus, Galit Parvari

|Jul 11, 2024
CF2H: a fascinating group for application in drug development enabling modulation of many molecular properties.

Sigal Saphier, Yossi Zafrani

|Sep 15, 2023
Species-specific lipophilicities of fluorinated diketones in complex equilibria systems and their potential as multifaceted reversible covalent warheads.

Ishay Columbus, Lee Ghindes-Azaria, Ido Michael Herzog

|Nov 14, 2022
Placing CF2 in the Center: Major Physicochemical Changes Upon a Minor Structural Alteration in Gem-Difunctional Compounds.

Sigal Saphier, Shahaf Katalan, Guy Yacov

|Jun 09, 2022
Studying Lipophilicity Trends of Phosphorus Compounds by 31P-NMR Spectroscopy: A Powerful Tool for the Design of P-Containing Drugs.

Ishay Columbus, Lee Ghindes-Azaria, Ravit Chen

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Frequent Collaborators

8 joint publications

Yossi Zafrani

5 joint publications

Yoav Eichen

5 joint publications

Ishay Columbus

3 joint publications

Galit Parvari