Sigal Saphier

10PUBLICATIONS
19CO-AUTHORS
Characterisation of biological macromoleculesCheminformatics and quantitative structure-activity relationshipsBiomolecular modelling and designF-block chemistryBasic pharmacology
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Publications (10)

|Oct 13, 2026
How Subtle Molecular Differences in the Morphinan Opioid Antagonists Affect Their Physicochemical and In Vitro ADME Properties.

|Feb 12, 2026
From NH+ Chemical Shifts to Chemical Insights: A 1H NMR Spectroscopic Window into Amine pKa, Anion pKBHX, and Charge-Assisted Intramolecular H-Bond Assessment from a Medicinal Chemistry Perspective.

Shlomi Elias, Dafna Amir, Boris Smolkin

|Jul 16, 2024
Addressing the Opioids Lipophilicity Challenge via a Straightforward and Simultaneous 1H NMR-Based logP/D Determination, Both Separately and in Mixtures.

Dina Yeffet, Ishay Columbus, Galit Parvari

|Sep 15, 2023
Species-specific lipophilicities of fluorinated diketones in complex equilibria systems and their potential as multifaceted reversible covalent warheads.

Ishay Columbus, Lee Ghindes-Azaria, Ido Michael Herzog

|Nov 14, 2022
Placing CF2 in the Center: Major Physicochemical Changes Upon a Minor Structural Alteration in Gem-Difunctional Compounds.

Sigal Saphier, Shahaf Katalan, Guy Yacov

|Jun 09, 2022
Studying Lipophilicity Trends of Phosphorus Compounds by 31P-NMR Spectroscopy: A Powerful Tool for the Design of P-Containing Drugs.

Ishay Columbus, Lee Ghindes-Azaria, Ravit Chen

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Frequent Collaborators

9 joint publications

Yossi Zafrani

6 joint publications

Yoav Eichen

5 joint publications

Ishay Columbus

4 joint publications

Galit Parvari