Jonathan R LaRochelle

3PUBLICATIONS
49CO-AUTHORS
Molecular targetsBiologically active molecules
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Publications (3)

|Nov 02, 2023
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.

Andreas Varkaris, Ermira Pazolli, Hakan Gunaydin

|Oct 31, 2018
Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.

Jonathan R LaRochelle, Michelle Fodor, Vidyasiri Vemulapalli

|Jan 06, 2018
Dual Allosteric Inhibition of SHP2 Phosphatase.

Michelle Fodor, Edmund Price, Ping Wang

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Frequent Collaborators

1 joint publications

Matthew J LaMarche

1 joint publications

Morvarid Mohseni

1 joint publications

Stephen C Blacklow

1 joint publications

Andreas Varkaris