Hakan Gunaydin
5PUBLICATIONS
114CO-AUTHORS
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Publications (5)
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|Nov 02, 2023
Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations.Andreas Varkaris, Ferran Fece de la Cruz, Elizabeth E Martin
|Nov 02, 2023
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.Andreas Varkaris, Ermira Pazolli, Hakan Gunaydin
|Jun 04, 2023
RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations.Vivek Subbiah, Vaibhav Sahai, Dejan Maglic
|Dec 08, 2022
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.David A Candito, Vladimir Simov, Anmol Gulati
|Sep 16, 2021
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.Min Lu, Hongjun Zhang, Derun Li
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Frequent Collaborators
2 joint publications
David E Shaw
2 joint publications
Yongli Ji
2 joint publications
Andreas Varkaris
2 joint publications
Donald A Bergstrom
2 joint publications
Levi Pierce
2 joint publications
Beni B Wolf
2 joint publications
Ermira Pazolli
2 joint publications
James Watters
2 joint publications
Alison M Schram
2 joint publications
Roberto Valverde
