Stephan Wilmes

7PUBLICATIONS
45CO-AUTHORS
Molecular targetsApplied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies)HaematologyCellular immunologyInnate immunity
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Publications (7)

|Dec 02, 2022
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.

Silvia Gaggero, Jonathan Martinez-Fabregas, Adeline Cozzani

|Aug 03, 2022
Structural insights into the assembly and activation of the IL-27 signaling complex.

Yibo Jin, Paul K Fyfe, Scott Gardner

|Apr 19, 2021
Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses.

Stephan Wilmes, Polly-Anne Jeffrey, Jonathan Martinez-Fabregas

|Jan 01, 2021
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.

Lu Cui, Ignacio Moraga, Tristan Lerbs

|Sep 16, 2020
Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses.

Claire Gorby, Junel Sotolongo Bellón, Stephan Wilmes

|Feb 08, 2020
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.

Stephan Wilmes, Maximillian Hafer, Joni Vuorio

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