James Spudich

19PUBLICATIONS

60CO-AUTHORS

Gene and molecular therapyCardiology (incl. cardiovascular diseases)Cell physiologyCellular immunologyMedical biochemistry - proteins and peptides (incl. medical proteomics)

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Publications (19)

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|Jul 07, 2026

Mavacamten shows broad benefit in human and mouse models of MYBPC3-related hypertrophic cardiomyopathy.

|Jun 04, 2026

Dynamics of the β-cardiac myosin auto-inhibited state explain cardiomyopathy pathogenesis.

|May 05, 2026

The hypertrophic cardiomyopathy myosin variant G256E prolongs cardiac muscle relaxation via altered nucleotide handling.

|Nov 24, 2025

The G256E HCM mutation prolongs cardiac muscle relaxation via altered nucleotide handling.

Michael Regnier, Kerry Kao, Matthew Childers

|Oct 01, 2025

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically.

Neha Nandwani, Debanjan Bhowmik, Camille Glaser

|Aug 20, 2025

A FRET assay to monitor different structural states of human β-cardiac myosin including the interacting-heads motif.

Rama Reddy Goluguri, Piyali Guhathakurta, Neha Nandwani

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Frequent Collaborators

Kathleen M Ruppel

Neha Nandwani

Anne Houdusse

Julien Robert-Paganin

Chao Liu

Daniel Bernstein

Divya Pathak

Michael Regnier

Daniel Auguin

Beth L Pruitt

Frequent Collaborators

Kathleen M Ruppel

Neha Nandwani

Anne Houdusse

Julien Robert-Paganin