Takuya Oguma

8PUBLICATIONS
9CO-AUTHORS
Clinical pharmacology and therapeuticsPharmacogenomicsBiologically active moleculesMicrobial geneticsPharmaceutical delivery technologies
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Publications (8)

|Aug 13, 2024
Dual 5-HT2A and 5-HT2C Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis.

Takuya Oguma, Kohei Jino, Kenji Nakahara

|Feb 16, 2023
A Quantum Mechanics-Based Method to Predict Intramolecular Hydrogen Bond Formation Reflecting P-glycoprotein Recognition.

Takuya Oguma, Shota Uehara, Kenji Nakahara

|Jul 29, 2022
Stereoselective Synthesis of Tricyclic β-Lactam by Sulfoxide-Directed Oxidative Lactonization from an Accessible Cephalosporin Intermediate.

Jun Sato, Takuya Oguma, Kenji Yamawaki

|Mar 17, 2022
Concise syntheses of GB22, GB13, and himgaline by cross-coupling and complete reduction.

Eleanor M Landwehr, Meghan A Baker, Takuya Oguma

|Feb 03, 2022
Discovery of a Tricyclic β-Lactam as a Potent Antimicrobial Agent against Carbapenem-Resistant Enterobacterales, Including Strains with Reduced Membrane Permeability and Four-Amino Acid Insertion into Penicillin-Binding Protein 3: Structure-Activity-Relationships and In Vitro and In Vivo Activities.

Jun Sato, Hiroki Kusano, Toshiaki Aoki

|Feb 16, 2021
Discovery of Atabecestat (JNJ-54861911): A Thiazine-Based β-Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor Advanced to the Phase 2b/3 EARLY Clinical Trial.

Yuji Koriyama, Akihiro Hori, Hisanori Ito

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Frequent Collaborators

5 joint publications

Kenichi Kusakabe

2 joint publications

Jun Sato

1 joint publications

Francois Bischoff

1 joint publications

Harrie J M Gijsen