David C Williams

9PUBLICATIONS
33CO-AUTHORS
HaematologyCharacterisation of biological macromoleculesAgricultural molecular engineering of nucleic acids and proteinsEpigenetics (incl. genome methylation and epigenomics)Gene and molecular therapy
Featured researcher

Get your video featured.

JoVEPublish with JoVE
Journal

Publications (9)

|Aug 01, 2026
Structure-guided targeting of the GATAD2A-CHD4 interaction within the MBD2-NuRD complex results in high levels of HbF in adult erythroid cells.

|Jun 12, 2026
Macrocycle screening against the C-terminal region of CHD4 uncovers its role as an interaction hub in the formation of the nucleosome remodeling and deacetylase complex.

|Jan 26, 2026
DNA methylation matters: methylation of the γ-globin (HBG) gene promoters is required for postnatal silencing of HbF.

Gordon D Ginder, Shengzhe Shang, David C Williams

|Jul 25, 2025
Methyl-CpG-binding domain as a protein interaction partner in promoter regulation and neurodevelopment through evolutionary expanded entanglement.

Stephanie M Bilinovich, Surya B Chhetri, Jackson T Mitchell

|Aug 08, 2023
Analysis of the complex between MBD2 and the histone deacetylase core of NuRD reveals key interactions critical for gene silencing.

Gage O Leighton, Shengzhe Shang, Sean Hageman

|Jun 12, 2023
MBD2a-NuRD binds to the methylated γ-globin gene promoter and uniquely forms a complex required for silencing of HbF expression.

Shengzhe Shang, Xia Li, Alexander Azzo

Pageof 2

Frequent Collaborators

3 joint publications

Gordon D Ginder

3 joint publications

Shengzhe Shang

2 joint publications

Gage O Leighton

2 joint publications

Mikhail Dozmorov