Samuel R Hildebrand

6PUBLICATIONS
35CO-AUTHORS
Cardiology (incl. cardiovascular diseases)Gene and molecular therapyBiologically active moleculesReaction engineering (excl. nuclear reactions)Glycoconjugates
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Publications (6)

|Aug 12, 2026
Blocking somatic repeat expansion and lowering huntingtin by RNAi synergize to attenuate Huntington's disease pathogenesis in mice.

|Dec 23, 2025
Potent and durable gene modulation in heart and muscle with chemically defined lipophilic siRNAs.

Hassan H Fakih, Clemens Lochmann, Rosemary Gagnon

|Jun 23, 2025
Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy.

Sarah M Davis, Samuel Hildebrand, Hannah J MacMillan

|May 10, 2024
A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system.

Jillian Belgrad, Qi Tang, Sam Hildebrand

|Apr 14, 2023
Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors.

Samuel R Hildebrand, Adam K Hedger, Ken Yamada

|Dec 01, 2021
Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.

Ken Yamada, Samuel Hildebrand, Sarah M Davis

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Frequent Collaborators

6 joint publications

Anastasia Khvorova

4 joint publications

Dimas Echeverria

4 joint publications

Julia F Alterman

4 joint publications

Ken Yamada