Hans E Purkey

6PUBLICATIONS
38CO-AUTHORS
Cheminformatics and quantitative structure-activity relationshipsMolecular targetsBiologically active molecules
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Publications (6)

|Mar 02, 2026
Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C.

Matthew L Landry, Sushant Malhotra, Maureen Beresini

|Mar 02, 2026
Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12C.

Nicholas F Endres, Steven Do, Rana Mroue

|Mar 06, 2023
Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry.

John C Tran, Thomas Hunsaker, Christina Bell

|Dec 01, 2022
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.

Emily J Hanan, Marie-Gabrielle Braun, Robert A Heald

|Jan 07, 2022
Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.

Christopher W Davies, Angela J Oh, Rana Mroue

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