Robert A Heald

10PUBLICATIONS
68CO-AUTHORS
Molecular targetsCellular nervous systemCheminformatics and quantitative structure-activity relationshipsCharacterisation of biological macromoleculesRadiation therapy
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Publications (10)

|Jul 13, 2026
The pharmacological profile of ART6043, a first-in-class clinical DNA polymerase theta polymerase domain inhibitor potentiating PARP inhibitor efficacy.

|Jun 12, 2026
SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy.

|Dec 08, 2025
Discovery of ART5537: A Potent and Selective Small-Molecule Probe for EXO1.

Sam E Mann, Owen A Davis, Jörg Bomke

|Nov 27, 2025
Design, Synthesis, and Biological Evaluation of the Novel Neutrophil Elastase Inhibitor CHF-6333 for the Inhaled Treatment of Bronchiectasis.

Elisabetta Armani, Andrea Rizzi, Daniela Miglietta

|Sep 17, 2025
Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor.

Sam E Mann, Julien Lefranc, Omar Alkhatib

|Dec 04, 2024
Discovery of ART0380, a Potent and Selective ATR Kinase Inhibitor Undergoing Phase 2 Clinical Studies for the Treatment of Advanced or Metastatic Solid Cancers.

Christopher L Carroll, Michael G Johnson, Yanbing Ding

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Frequent Collaborators

5 joint publications

Claire McWhirter

5 joint publications

Eeson Rajendra

4 joint publications

Alessandro Galbiati

4 joint publications

Geoff S Higgins