Graeme C M Smith

5PUBLICATIONS
96CO-AUTHORS
Molecular targetsRadiation therapyCharacterisation of biological macromolecules
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Publications (5)

|Jul 13, 2026
The pharmacological profile of ART6043, a first-in-class clinical DNA polymerase theta polymerase domain inhibitor potentiating PARP inhibitor efficacy.

|Jun 12, 2026
SHLD2 loss is a synthetic vulnerability to Polθ inhibition combined with radiotherapy.

|Feb 28, 2024
Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types.

Patrick G Pilié, Virginia Giuliani, Wei-Lien Wang

|Jan 23, 2023
Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models.

Gonzalo Rodriguez-Berriguete, Marco Ranzani, Remko Prevo

|Jun 18, 2021
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.

Diana Zatreanu, Helen M R Robinson, Omar Alkhatib

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Frequent Collaborators

5 joint publications

Eeson Rajendra

4 joint publications

Helen M R Robinson

4 joint publications

Marco Ranzani

4 joint publications

Jayesh Majithiya